Casp4^del
Spontaneous Allele Detail

Summary

• Symbol: Casp4^del
• Name: caspase 4, apoptosis-related cysteine peptidase; deletion
• MGI ID: MGI:5473345
• Synonyms: Casp¹²⁹
• Gene: Casp4 Location: Chr9:5308828-5336783 bp, + strand Genetic Position: Chr9, 2.46 cM, cytoband A1
• Alliance: Casp4^del page

Mutation origin

• Strain of Origin: 129P3/J and 129S1/SvImJ and 129S2/SvPas and 129S6/SvEvTac and 129X1/SvJ

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: RT-PCR confirmed that five 129 substrains (129X1/SvJ, 129S1/SvImJ, 129S2/SvPas, 129S6/SvEvTac and 129P3/J) express a transcript that lacks exon 7 (delta110 isoform). Sequencing identified a 5 bp deletion in exon 7 that results in the fusion of exon 6 and 8, a frame-shift after proline 304 and a stop codon after 5 aberrant amino acids. This deletion is not present in C57BL/6. Western blot analysis confirmed the absence of protein expression in LPS-primed macrophage. (J:193522)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Casp4 Mutation: 33 strains or lines available

References

• Original: J:193522 Kayagaki N, et al., Non-canonical inflammasome activation targets caspase-11. Nature. 2011 Nov 3;479(7371):117-21
• All: 68 reference(s)