Gad2^{tm1.1(cre/ERT2)Gmbk}
Targeted Allele Detail

Summary

• Symbol: Gad2^{tm1.1(cre/ERT2)Gmbk}
• Name: glutamic acid decarboxylase 2; targeted mutation 1.1, Gero Miesenboeck
• MGI ID: MGI:5473402
• Synonyms: Gad2::Cre-ER^T2
• Gene: Gad2 Location: Chr2:22512262-22583889 bp, + strand Genetic Position: Chr2, 15.15 cM, cytoband A-B
• Alliance: Gad2^{tm1.1(cre/ERT2)Gmbk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194305
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Gad2^{tm1.1(cre/ERT2)Gmbk} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gad2 (MGI:95634)

• Mutation details: A cassette encoding IRES-cre/ERT2 fused to an Frt-flanked neo resistance marker was inserted into the 3' untranslated region of the Gad2 gene immediately following the stop codon. The neo marker was excised excised by breeding founder animals ot Flp-expressing mice. (J:194305)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gad2 (mouse) Summary of all recombinase alleles driven by Gad2. Alliance mouse Gad2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gad2 Mutation: 60 strains or lines available

References

• Original: J:194305 Katzel D, et al., The columnar and laminar organization of inhibitory connections to neocortical excitatory cells. Nat Neurosci. 2011 Jan;14(1):100-7
• All: 9 reference(s)