Pomc^tm2Low
Targeted Allele Detail

Summary

• Symbol: Pomc^tm2Low
• Name: pro-opiomelanocortin-alpha; targeted mutation 2, Malcolm J Low
• MGI ID: MGI:5473420
• Synonyms: arcPomc^-, Pomc^NEO
• Gene: Pomc Location: Chr12:4004951-4010642 bp, + strand Genetic Position: Chr12, 1.99 cM
• Alliance: Pomc^tm2Low page

Obesity in Pomc^tm2Low/Pomc^tm2Low Tg(CAG-cre/Esr1*)5Amc/0 females and weight loss following tamoxifen treatment

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194013
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

Allele Type: Targeted (Modified isoform(s), Modified regulatory region) Mutation: Insertion Mutation details: A floxed neo cassette was inserted between the first upstream neuronal enhancer (nPE1) and the deleted second neuronal enhancer (nPE2). The pituitary enhancer/promoter is not affected. Immunohistochemistry confirmed the lack of neuronal transcription in the hypothalamic arcuate nucleus (Arc) and normal expression in pituitary cells. (J:194013)

Schematic of the Pomc^tm2Low allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pomc Mutation: 21 strains or lines available

References

• Original: J:194013 Bumaschny VF, et al., Obesity-programmed mice are rescued by early genetic intervention. J Clin Invest. 2012 Nov 1;122(11):4203-12
• All: 14 reference(s)