Mcm4^Sdla
Spontaneous Allele Detail

Summary

• Symbol: Mcm4^Sdla
• Name: minichromosome maintenance complex component 4; Spontaneous dominant leukemia
• MGI ID: MGI:5473704
• Synonyms: Mcm4^D573H, Sdl
• Gene: Mcm4 Location: Chr16:15441761-15455264 bp, - strand Genetic Position: Chr16, 10.09 cM, cytoband B1
• Alliance: Mcm4^Sdla page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A spontaneous mutation in mice carrying Gt(ROSA)26Sor^{tm1(sb11)Njen} produces G-to-C transversion that results in the amino acid substitution of aspartic acid with histidine at position 573 (p.D573H). Western blot analysis confirmed protein expression in mouse embryonic fibroblasts. (J:194117)
• Inheritance: Dominant

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mcm4 Mutation: 43 strains or lines available

References

• Original: J:194117 Bagley BN, et al., A dominantly acting murine allele of Mcm4 causes chromosomal abnormalities and promotes tumorigenesis. PLoS Genet. 2012;8(11):e1003034
• All: 1 reference(s)