Mob1a^tm1.1Asuz
Targeted Allele Detail

Summary

• Symbol: Mob1a^tm1.1Asuz
• Name: MOB kinase activator 1A; targeted mutation 1.1, Akira Suzuki
• MGI ID: MGI:5473804
• Synonyms: Mob1a^flox
• Gene: Mob1a Location: Chr6:83303016-83320758 bp, + strand Genetic Position: Chr6, 35.94 cM
• Alliance: Mob1a^tm1.1Asuz page

Skin and hair abnormalities and large paws in tamoxifen treated Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Tg(KRT14-cre/ERT)20Efu/0 Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193981
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 2. Cre-mediated recombination removed the neo cassette and left exon 2 floxed. (J:193981)

Targeting strategy for the generation of Mob1a^tm1.1Asuz and Mob1a^tm1.2Asuz alleles

Tumor Data

List all tumor models in MMHCdb carrying Mob1a^tm1.1Asuz

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mob1a Mutation: 18 strains or lines available

References

• Original: J:193981 Nishio M, et al., Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J Clin Invest. 2012 Dec 3;122(12):4505-18
• All: 9 reference(s)