Tg(CAG-Bmpr1a*,-lacZ)1Nobs
Transgene Detail
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Symbol: |
Tg(CAG-Bmpr1a*,-lacZ)1Nobs |
Name: |
transgene insertion 1, Noboru Suzuki |
MGI ID: |
MGI:5473821 |
Synonyms: |
Tg(CAG-flox-dnBmpr1a-NLLacZ)1Nobs |
Transgene: |
Tg(CAG-Bmpr1a*,-lacZ)1Nobs Location: unknown
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Alliance: |
Tg(CAG-Bmpr1a*,-lacZ)1Nobs page
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Strain of Origin: |
C57BL/6J x B6;129X1-Pcp2tm1(cre)Nobs
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Transgene Type: |
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Transgenic (Conditional ready, Dominant negative, Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Tg(CAG-Bmpr1a*,-lacZ)1Nobs expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Bmpr1a (MGI:1338938) |
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Mutation details: This transgene consists of the CAG promoter, loxP flanked stop codon, a 0.6 kb dominant-negative mouse Bmpr1a cDNA lacking the intracellular kinase domain (Y176STOP), a 0.5 kb internal ribosomal entry site (IRES), a 3.5 kb lacZ gene containing the nuclear localization signal, and a polyadenylation signal. Upon Cre-mediated excision of the Stop codon, the modified allele expresses the dominant negative Bmpr1a and lacZ in tissues where Cre is expressed.
(J:192670)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:192670 Saito H, et al., Reduced bone morphogenetic protein receptor type 1A signaling in neural-crest-derived cells causes facial dysmorphism. Dis Model Mech. 2012 Nov;5(6):948-55 |
All: |
1 reference(s) |
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