Ptp4a3^tm1.1Geh
Targeted Allele Detail

Summary

• Symbol: Ptp4a3^tm1.1Geh
• Name: protein tyrosine phosphatase 4a3; targeted mutation 1.1, Gregg E Homanics
• MGI ID: MGI:5473867
• Gene: Ptp4a3 Location: Chr15:73594991-73629075 bp, + strand Genetic Position: Chr15, 34.05 cM, cytoband E1
• Alliance: Ptp4a3^tm1.1Geh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194458
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2. This allele lacks the neo cassette (removed by either flp- or cre-mediated recombination). Western blot analysis confirmed the absence of protein expression in the fetal heart, fetal intestine, adult heart, skeletal muscle, pancreas, lung, spleen, brain, thymus, colon and small intestine. (J:194458)

Details of the generation of the Ptp4a3^tm1Geh and Ptp4a3^tm1.1Geh alleles

Expression

In Mice Carrying this Mutation:	24 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptp4a3 Mutation: 15 strains or lines available

References

• Original: J:194458 Zimmerman MW, et al., Targeted Deletion of the Metastasis-Associated Phosphatase Ptp4a3 (PRL-3) Suppresses Murine Colon Cancer. PLoS One. 2013;8(3):e58300
• All: 2 reference(s)