Alkbh5^tm1.1Klng
Targeted Allele Detail

Summary

• Symbol: Alkbh5^tm1.1Klng
• Name: alkB homolog 5, RNA demethylase; targeted mutation 1.1, Arne Klungland
• MGI ID: MGI:5473894
• Gene: Alkbh5 Location: Chr11:60428509-60449338 bp, + strand Genetic Position: Chr11, 37.81 cM
• Alliance: Alkbh5^tm1.1Klng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194218
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. A neo cassette with a 3' loxP site was inserted downstream of exon 1. Cre-mediated recombination removed exon 1 and the neo cassette. RNA in situ hybridization confirmed the absence of transcript expression. (J:194218)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alkbh5 Mutation: 18 strains or lines available

References

• Original: J:194218 Zheng G, et al., ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell. 2013 Jan 10;49(1):18-29
• All: 2 reference(s)