Trib3^tm1Tord
Targeted Allele Detail

Summary

• Symbol: Trib3^tm1Tord
• Name: tribbles pseudokinase 3; targeted mutation 1, Tonis Ord
• MGI ID: MGI:5474051
• Gene: Trib3 Location: Chr2:152179342-152185952 bp, - strand Genetic Position: Chr2, 74.83 cM
• Alliance: Trib3^tm1Tord page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192615
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region (exons 2 - 4) were replaced with a pgk-neo cassette via homologous recombination. RT-qPCR confirmed the absence of mRNA expression in bone marrow derived mast cells and livers from homozygous mice. (J:192615)

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trib3 Mutation: 17 strains or lines available

References

• Original: J:192615 Ord T, et al., Trib3 is regulated by IL-3 and affects bone marrow-derived mast cell survival and function. Cell Immunol. 2012 Nov;280(1):68-75
• All: 4 reference(s)