Tg(CD68-icre)1Bwlx
Transgene Detail

Summary

• Symbol: Tg(CD68-icre)1Bwlx
• Name: transgene insertion 1, Ben Wielockx
• MGI ID: MGI:5474196
• Synonyms: CD68:cre
• Transgene: Tg(CD68-icre)1Bwlx Location: unknown
• Alliance: Tg(CD68-icre)1Bwlx page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(CD68-icre)1Bwlx expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  CD68 (968)

  Cd68	(MGI:88342)

• Mutation details: A 2.9 kb fragment of the 5' flanking sequence and the 83-bp first intron of the human CD68 gene was cloned into a vector in front of codon-improved cre and polyadenylation sequences. 2 founder lines were selected for analysis, based on expression levels in isolated peritoneal F4/80+ cells. One line expressed cre in sperm and egg cells so the other line was used for further studies. (J:194598)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	CD68 (human) Summary of all recombinase alleles driven by CD68. Alliance human CD68 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:194598 Franke K, et al., HIF-1alpha is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2alpha-induced excessive erythropoiesis. Blood. 2013 Feb 21;121(8):1436-45
• All: 5 reference(s)