Bbs1^tm2Vcs
Targeted Allele Detail

Summary

• Symbol: Bbs1^tm2Vcs
• Name: Bardet-Biedl syndrome 1; targeted mutation 2, Val C Sheffield
• MGI ID: MGI:5474481
• Synonyms: Bbs1^loxP
• Gene: Bbs1 Location: Chr19:4936906-4956656 bp, - strand Genetic Position: Chr19, 4.14 cM
• Alliance: Bbs1^tm2Vcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194096
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 3 was flanked by loxP sites. (J:194096)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bbs1 Mutation: 71 strains or lines available

References

• Original: J:194096 Carter CS, et al., Abnormal development of NG2+PDGFR-alpha+ neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model. Nat Med. 2012 Dec;18(12):1797-804
• All: 8 reference(s)