Flvcr1^tm1Etol
Targeted Allele Detail

Summary

• Symbol: Flvcr1^tm1Etol
• Name: feline leukemia virus subgroup C cellular receptor 1; targeted mutation 1, Emanuela Tolosano
• MGI ID: MGI:5474636
• Synonyms: Flvcr1a^-
• Gene: Flvcr1 Location: Chr1:190738044-190758355 bp, - strand Genetic Position: Chr1, 96.28 cM
• Alliance: Flvcr1^tm1Etol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194202
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Modified isoform(s)) Mutation: Insertion Mutation details: A neo cassette was inserted into the ATG start codon in the first exon. RT-PCR confirmed the absence of transcripts for isoform a in E13.5 embyos but an increase in isoform b transcripts. (J:194202)

Generation of the Flvcr1^tm1Etol allele

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Flvcr1 Mutation: 32 strains or lines available

References

• Original: J:194202 Chiabrando D, et al., The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation. J Clin Invest. 2012 Dec 3;122(12):4569-79
• All: 1 reference(s)