Ezh1^tm1Sgon
Targeted Allele Detail

Summary

• Symbol: Ezh1^tm1Sgon
• Name: enhancer of zeste 1 polycomb repressive complex 2 subunit; targeted mutation 1, Susana Gonzalez
• MGI ID: MGI:5474772
• Synonyms: Ezh1^fl
• Gene: Ezh1 Location: Chr11:101081941-101117268 bp, - strand Genetic Position: Chr11, 64.37 cM, cytoband C-D
• Alliance: Ezh1^tm1Sgon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193722
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 17. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 18. (J:193722)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ezh1 Mutation: 34 strains or lines available

References

• Original: J:193722 Hidalgo I, et al., Ezh1 Is Required for Hematopoietic Stem Cell Maintenance and Prevents Senescence-like Cell Cycle Arrest. Cell Stem Cell. 2012 Nov 2;11(5):649-62
• All: 2 reference(s)