Gt(ROSA)26Sor^{tm1(CAG-NR2F1)Mjts}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-NR2F1)Mjts}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ming-Jer Tsai
• MGI ID: MGI:5474793
• Synonyms: CAG-S-hCOUP-TFI
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-NR2F1)Mjts} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162256
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-NR2F1)Mjts} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NR2F1 (7025)

  Nr2f1

  (MGI:1352451)

• Mutation details: A conditional over-expression cassette was inserted into the locus. The cassette contains a CAG promoter, floxed STOP cassette, FLAG- and myc-tagged human cDNA and polyadenylation sequence. (J:162256)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:162256 Wu SP, et al., Generation of ES cells for conditional expression of nuclear receptors and coregulators in vivo. Mol Endocrinol. 2010 Jun;24(6):1297-304
• All: 3 reference(s)