Impa2^tm1.2Tohn
Targeted Allele Detail

Summary

• Symbol: Impa2^tm1.2Tohn
• Name: inositol monophosphatase 2; targeted mutation 1.2, Tetsuo Ohnishi
• MGI ID: MGI:5474837
• Gene: Impa2 Location: Chr18:67422246-67454375 bp, + strand Genetic Position: Chr18, 39.92 cM
• Alliance: Impa2^tm1.2Tohn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193924
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxp site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2. This allele lacks the neo cassette. Western blot analysis confirmed the absence of protein expression in the cortex, cerebellum, salivary gland, kidney, thymus and small intestine. (J:193924)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Impa2 Mutation: 27 strains or lines available

References

• Original: J:193924 Ohnishi T, et al., Human myo-inositol monophosphatase 2 rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genes. J Neurochem. 2013 Mar;124(5):685-94
• All: 1 reference(s)