Igs1tm8(CAG-Bgeo,-HIST1H2BB/EGFP)Nat
Targeted Allele Detail
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Symbol: |
Igs1tm8(CAG-Bgeo,-HIST1H2BB/EGFP)Nat |
Name: |
intergenic site 1; targeted mutation 8, Jeremy Nathans |
MGI ID: |
MGI:5474845 |
Synonyms: |
Iis1tm8(CAG-Bgeo,-HIST1H2BB/EGFP)Nat, Z/H2B-GFP |
Gene: |
Igs1 Location: unknown Genetic Position: Chr11, Syntenic
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Alliance: |
Igs1tm8(CAG-Bgeo,-HIST1H2BB/EGFP)Nat page
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Germline Transmission: |
Earliest citation of germline transmission:
J:193332
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutation: |
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Insertion
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Mutation details: A site 5' of the Ubb gene was targeted with a construct composed of a CMV/beta-actin enhancer and promoter (CAG), a floxed beta-geo with three transcription termination sites and an HIST1H2BB and GFP (H2B-GFP) fusion. Cre-mediated excision of the floxed beta-geo construct is required to achieve expression of the H2B-GFP cassette.
(J:193332)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Igs1 Mutation: |
10 strains or lines available
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Original: |
J:193332 Wang Y, et al., Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity. Cell. 2012 Dec 7;151(6):1332-44 |
All: |
2 reference(s) |
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