Kcnk6^tm1Tigm
Targeted Allele Detail

Summary

• Symbol: Kcnk6^tm1Tigm
• Name: potassium inwardly-rectifying channel, subfamily K, member 6; targeted mutation 1, Texas A&M Institute for Genomic Medicine
• MGI ID: MGI:5474993
• Synonyms: K2P6.1^{Tm(TG0009)Tigm}, TWIK-2 KO
• Gene: Kcnk6 Location: Chr7:28921351-28931940 bp, - strand Genetic Position: Chr7, 16.94 cM
• Alliance: Kcnk6^tm1Tigm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194443
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ and neo cassette replaced exon 1, which encodes the first transmembrane domain, the first pore region and the site for dimerization. RT-PCR confirmed the absence of transcript expression in the thoracic aorta and whole heart. (J:194443)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Kcnk6 Mutation: 11 strains or lines available

References

• Original: J:194443 Lloyd EE, et al., Disruption of K(2P)6.1 produces vascular dysfunction and hypertension in mice. Hypertension. 2011 Oct;58(4):672-8
• All: 5 reference(s)