Nr3c2^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Nr3c2^tm1.1Ics
• Name: nuclear receptor subfamily 3, group C, member 2; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5474998
• Synonyms: MR^f
• Gene: Nr3c2 Location: Chr8:77626422-77971641 bp, + strand Genetic Position: Chr8, 36.34 cM
• Alliance: Nr3c2^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193438
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 5 and 6 were floxed. Recombination removed the selection cassette. (J:193438)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nr3c2 Mutation: 53 strains or lines available

References

• Original: J:193438 McCurley A, et al., Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat Med. 2012 Sep;18(9):1429-33
• All: 15 reference(s)