Tg(Msr1-MMP9)#Apar
Transgene Detail

Summary

• Symbol: Tg(Msr1-MMP9)#Apar
• Name: transgene insertion, Annie Pardo
• MGI ID: MGI:5475005
• Synonyms: hMMP9-TG
• Transgene: Tg(Msr1-MMP9)#Apar Location: unknown
• Alliance: Tg(Msr1-MMP9)#Apar page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Msr1-MMP9)#Apar expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MMP9 (4318)

  Mmp9	(MGI:97011)

• Mutation details: The scavenger receptor A enhancer-promoter drives expression of human MMP9 (2.4 kb cDNA). The Msr1 promoter drives expression specifically in differentiated macrophages. Zymography confirmed expression of MMP9 in peritoneal macrophages. Two lines were established. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:129959)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:129959 Cabrera S, et al., Overexpression of MMP9 in macrophages attenuates pulmonary fibrosis induced by bleomycin. Int J Biochem Cell Biol. 2007;39(12):2324-38
• All: 3 reference(s)