Gbp2^tm1.1Kpf
Targeted Allele Detail

Summary

• Symbol: Gbp2^tm1.1Kpf
• Name: guanylate binding protein 2; targeted mutation 1.1, Klaus Pfeffer
• MGI ID: MGI:5475104
• Gene: Gbp2 Location: Chr3:142326424-142343769 bp, + strand Genetic Position: Chr3, 66.69 cM
• Alliance: Gbp2^tm1.1Kpf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192526
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutation: Insertion Mutation details: A DsRed reporter and floxed neomycin resistance cassette was inserted in exon 2 causing a frame shift and a premature stop codon. The selection cassette was subsequently excised by cre recombination. Western blot analysis confirmed loss of gene expression. (J:192526)

Generation of the Gbp2^tm1.1Kpf allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gbp2 Mutation: 28 strains or lines available

References

• Original: J:192526 Degrandi D, et al., Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replication. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):294-9
• All: 8 reference(s)