Pkn1^tm1Kik
Targeted Allele Detail

Summary

• Symbol: Pkn1^tm1Kik
• Name: protein kinase N1; targeted mutation 1, Hitoshi Kikutani
• MGI ID: MGI:5475202
• Gene: Pkn1 Location: Chr8:84393165-84425808 bp, - strand Genetic Position: Chr8, 40.22 cM
• Alliance: Pkn1^tm1Kik page

Development of glomerulonephritis in Pkn1^tm1Kik/Pkn1^tm1Kik mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193187
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 4 through 6 were replaced with a neo cassette. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts and B cells. (J:193187)

Generation of the Pkn1^tm1Kik allele

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkn1 Mutation: 45 strains or lines available

References

• Original: J:193187 Yasui T, et al., Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21022-7
• All: 1 reference(s)