Bcl11a^tm2.1Peli
Targeted Allele Detail

Summary

• Symbol: Bcl11a^tm2.1Peli
• Name: BCL11 transcription factor A; targeted mutation 2.1, Pentao Liu
• MGI ID: MGI:5475336
• Synonyms: Bcl11a^flox
• Gene: Bcl11a Location: Chr11:24028056-24124123 bp, + strand Genetic Position: Chr11, 14.41 cM
• Alliance: Bcl11a^tm2.1Peli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194616
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette and left exon 4 floxed. (J:194959)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl11a Mutation: 44 strains or lines available

References

• Original: J:194616 Yu Y, et al., Bcl11a is essential for lymphoid development and negatively regulates p53. J Exp Med. 2012 Dec 17;209(13):2467-83
• All: 5 reference(s)