Cdkl5^tm1.1Joez
Targeted Allele Detail

Summary

• Symbol: Cdkl5^tm1.1Joez
• Name: cyclin dependent kinase like 5; targeted mutation 1.1, Zhaolan Zhou
• MGI ID: MGI:5475468
• Gene: Cdkl5 Location: ChrX:159567241-159777673 bp, - strand Genetic Position: ChrX, 73.95 cM
• Alliance: Cdkl5^tm1.1Joez page

Hindlimb clasping in Cdkl5^tm1.1Joez/Y mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193172
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A floxed neo cassette was inserted upstream of exon 6. A loxP site was inserted downstream of exon 6. Cre-mediated recombination removed the neo cassette and exon 6. Western blot analysis confirmed the absence of protein expression. (J:193172)

Generation of the Cdkl5^tm1.1Joez allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkl5 Mutation: 20 strains or lines available

References

• Original: J:193172 Wang IT, et al., Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21516-21
• All: 13 reference(s)