Tg(Eno2-MFN2)L916Ugfm
Transgene Detail

Summary

• Symbol: Tg(Eno2-MFN2)L916Ugfm
• Name: transgene insertion L916, University of Geneva Faculty of Medicine
• MGI ID: MGI:5476630
• Synonyms: hMFN2Wt, hMFN2WtL916, MitoCharc0
• Transgene: Tg(Eno2-MFN2)L916Ugfm Location: unknown
• Alliance: Tg(Eno2-MFN2)L916Ugfm page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Eno2-MFN2)L916Ugfm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MFN2 (9927)

  Mfn2	(MGI:2442230)

• Mutation details: This transgene contains the rat neuron-specific enolase 2 gene promoter driving expression of the the wild-type human mitofusin 2 gene, which is followed by the SV40 polyadenylation signal. Expression of human MFN2 mRNA was demonstrated by reverse transcription-polymerase chain reaction (RT-PCR) analysis in spinal cord, dorsal root ganglion, whole brain, cortex, brainstem and cerebellum, but not in pancreas, of transgenic mice; trangene expression increases the total Mfn2/MFN2 transcript level in spinal cord to 2.3-fold that of the endogenous mouse transcript, as determined by semi-quantitative RT-PCR. (J:173431)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:173431 Cartoni R, et al., Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A. Brain. 2010 May;133(Pt 5):1460-9
• All: 2 reference(s)