Trp53^tm1Yjc
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1Yjc
• Name: transformation related protein 53; targeted mutation 1, Y Jeffrey Chiang
• MGI ID: MGI:5476675
• Synonyms: p53^rev
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1Yjc page

Trp53^tm1Yjc/Trp53^tm1Yjc mice develop B cell lymphomas

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195018
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

Allele Type: Targeted (Not Applicable) Mutation: Insertion Mutation details: A floxed neo cassette was inserted into exon 1. Western blot analysis confirmed reduced protein expression in the spleen. Cre-mediated recombination is required to restore full expression levels. (J:195018)

Generation of the Trp53^tm1Yjc allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 240 strains or lines available

References

• Original: J:195018 Chiang YJ, et al., Exon 1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomas. PLoS One. 2012;7(11):e49305
• All: 1 reference(s)