Camk2dtm1.1Jhb
Targeted Allele Detail
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Symbol: |
Camk2dtm1.1Jhb |
Name: |
calcium/calmodulin-dependent protein kinase II, delta; targeted mutation 1.1, Joan Heller Brown |
MGI ID: |
MGI:5476688 |
Gene: |
Camk2d Location: Chr3:126389951-126639975 bp, + strand Genetic Position: Chr3, 55.97 cM
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Alliance: |
Camk2dtm1.1Jhb page
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Camk2dtm1.1Jhb/Camk2dtm1.1Jhb hearts show a decreased response to induced stress
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:149675
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted upstream of exon 9. An FRT-flanked neo cassette with a 5' loxP site was inserted downsteam of exon 11. Cre-mediated recombination removed exons 9 through 11. The FRT-flanked neo cassette remains intact. Western blot analysis confirmed the absence of protein expression in the left ventricle.
(J:149675)
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Generation of the Camk2dtm1.1Jhb allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Camk2d Mutation: |
44 strains or lines available
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Original: |
J:149675 Ling H, et al., Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest. 2009 May;119(5):1230-40 |
All: |
9 reference(s) |
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