Camk2d^tm1.1Jhb
Targeted Allele Detail

Summary

• Symbol: Camk2d^tm1.1Jhb
• Name: calcium/calmodulin-dependent protein kinase II, delta; targeted mutation 1.1, Joan Heller Brown
• MGI ID: MGI:5476688
• Gene: Camk2d Location: Chr3:126389951-126639975 bp, + strand Genetic Position: Chr3, 55.97 cM
• Alliance: Camk2d^tm1.1Jhb page

Camk2d^tm1.1Jhb/Camk2d^tm1.1Jhb hearts show a decreased response to induced stress

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149675
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 9. An FRT-flanked neo cassette with a 5' loxP site was inserted downsteam of exon 11. Cre-mediated recombination removed exons 9 through 11. The FRT-flanked neo cassette remains intact. Western blot analysis confirmed the absence of protein expression in the left ventricle. (J:149675)

Generation of the Camk2d^tm1.1Jhb allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camk2d Mutation: 44 strains or lines available

References

• Original: J:149675 Ling H, et al., Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest. 2009 May;119(5):1230-40
• All: 10 reference(s)