Rgs4^tm1.1Amus
Targeted Allele Detail

Summary

• Symbol: Rgs4^tm1.1Amus
• Name: regulator of G-protein signaling 4; targeted mutation 1.1, Anthony J Muslin
• MGI ID: MGI:5476691
• Gene: Rgs4 Location: Chr1:169569046-169575211 bp, - strand Genetic Position: Chr1, 76.84 cM
• Alliance: Rgs4^tm1.1Amus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195186
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 5. Cre-mediated recombination removed exons 2 through 5 and the neo cassette. RT-PCR confirmed the absence of transcript expression in cardiac tissue. (J:195186)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rgs4 Mutation: 22 strains or lines available

References

• Original: J:195186 Siedlecki A, et al., RGS4 controls renal blood flow and inhibits cyclosporine-mediated nephrotoxicity. Am J Transplant. 2010 Feb;10(2):231-41
• All: 3 reference(s)