Nle1^rs13468707-C
Spontaneous Allele Detail

Summary

• Symbol: Nle1^rs13468707-C
• Name: notchless homolog 1; rs13468707 SNP allele with the C variant
• MGI ID: MGI:5476692
• Synonyms: Nle1^rs2820949-G
• Gene: Nle1 Location: Chr11:82791594-82799237 bp, - strand Genetic Position: Chr11, 50.3 cM
• Alliance: Nle1^rs13468707-C page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: This is the minor variant of SNP rs13468707 (c.538G>A substitution leading to p.I180V) in exon 6 and codes for the mutant valine in place of the evolutionary conserved isoleucine. The C variant is found in the C57BL/6NJ, AKR/J, BALB/cJ, BALB/CBYJ, DBA/2J, FVB/NJ, NOD/LTJ ,NOD/ShiLtJ, NZO/HILtJ, and NZW/LacJ strains. This SNP is the equivalent of the well-documented human SNP rs2820949. (J:193532)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nle1 Mutation: 27 strains or lines available

References

• Original: J:193532 Lossie AC, et al., ENU mutagenesis reveals that Notchless homolog 1 (Drosophila) affects Cdkn1a and several members of the Wnt pathway during murine pre-implantation development. BMC Genet. 2012;13:106
• All: 1 reference(s)