Map3k8^tm1.1Gkl
Targeted Allele Detail

Summary

• Symbol: Map3k8^tm1.1Gkl
• Name: mitogen-activated protein kinase kinase kinase 8; targeted mutation 1.1, George Kollias
• MGI ID: MGI:5476710
• Synonyms: Tpl2^fl
• Gene: Map3k8 Location: Chr18:4331325-4352978 bp, - strand Genetic Position: Chr18, 2.73 cM
• Alliance: Map3k8^tm1.1Gkl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193546
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 4 was floxed. Cre-mediated recombination removed the floxed neo cassette and left exon 4 floxed. (J:193546, J:216678)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Map3k8 Mutation: 41 strains or lines available

References

• Original: J:193546 Koliaraki V, et al., Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis. J Clin Invest. 2012 Nov 1;122(11):4231-42
• All: 6 reference(s)