Il36rn^tm1Kopf
Targeted Allele Detail

Summary

• Symbol: Il36rn^tm1Kopf
• Name: interleukin 36 receptor antagonist; targeted mutation 1, Manfred Kopf
• MGI ID: MGI:5476725
• Synonyms: Il36rn^-
• Gene: Il36rn Location: Chr2:24166966-24172444 bp, + strand Genetic Position: Chr2, 16.31 cM
• Alliance: Il36rn^tm1Kopf page

Il1rl2^tm1Hblu/Il1rl2^tm1Hblu and Il36rn^tm1Kopf/Il36rn^tm1Kopf mice show different susceptibilities to IMQ-induced psoriasiform dermatitis

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193548
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neo cassette replaced most of exon 1 and all of exon 2. RT-PCR confirmed the absence of transcript expression in the lung and stomach. (J:193548)

Generation of the Il36rn^tm1Kopf allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il36rn Mutation: 22 strains or lines available

References

• Original: J:193548 Tortola L, et al., Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk. J Clin Invest. 2012 Nov 1;122(11):3965-76
• All: 2 reference(s)