Tg(TARDBP*A315T)#Jpj
Transgene Detail

Summary

• Symbol: Tg(TARDBP*A315T)#Jpj
• Name: transgene insertion, Jean-Pierre Julien
• MGI ID: MGI:5476824
• Synonyms: TDP-43^A315T
• Transgene: Tg(TARDBP*A315T)#Jpj Location: unknown
• Alliance: Tg(TARDBP*A315T)#Jpj page

Transgene origin

• Strain of Origin: C3H x C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(TARDBP*A315T)#Jpj expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TARDBP (23435)

  Tardbp

  (MGI:2387629)

• Mutation details: This transgene consists of TARDBP amplified by PCR from a human BAC clone (clone RPCI-11, clone number 829B14) with the endogenous promoter and an A315T mutation inserted using site-directed mutagenesis. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:195184)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:195184 Swarup V, et al., Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments. Brain. 2011 Sep;134(Pt 9):2610-26
• All: 3 reference(s)