Ntrk2^tm2.1Tes
Targeted Allele Detail

Summary

• Symbol: Ntrk2^tm2.1Tes
• Name: neurotrophic tyrosine kinase, receptor, type 2; targeted mutation 2.1, Lino Tessarollo
• MGI ID: MGI:5476922
• Synonyms: Trkb^S478A
• Gene: Ntrk2 Location: Chr13:58954383-59281784 bp, + strand Genetic Position: Chr13, 31.2 cM
• Alliance: Ntrk2^tm2.1Tes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193542
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 12 was replaced with a modified exon in which nucleotide substitutions (CAGC to AGCA) results in the amino acid substitution of alanine for serine at position 478 (S478A). Cre-mediated recombination removed the floxed neo cassette inserted downstream of the modified exon 12. (J:193542)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntrk2 Mutation: 66 strains or lines available

References

• Original: J:193542 Lai KO, et al., TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat Neurosci. 2012 Nov;15(11):1506-15
• All: 1 reference(s)