Mutyh^tm1Yun
Targeted Allele Detail

Summary

• Symbol: Mutyh^tm1Yun
• Name: mutY DNA glycosylase; targeted mutation 1, Yusaku Nakabeppu
• MGI ID: MGI:5476928
• Gene: Mutyh Location: Chr4:116664920-116676637 bp, + strand Genetic Position: Chr4, 53.34 cM, cytoband C7
• Alliance: Mutyh^tm1Yun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195260
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S/Sv

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neo cassette replaces exons 8 through 15. Western blot analysis confirmed the absence of protein expression in ES cells. (J:195260)

Generation of the Mutyh^tm1Yun allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mutyh Mutation: 36 strains or lines available

Notes

ES cell = CCE28

References

• Original: J:195260 Hirano S, et al., Mutator phenotype of MUTYH-null mouse embryonic stem cells. J Biol Chem. 2003 Oct 3;278(40):38121-4
• All: 4 reference(s)