Rhbg^tm1.1Idw
Targeted Allele Detail

Summary

• Symbol: Rhbg^tm1.1Idw
• Name: Rhesus blood group-associated B glycoprotein; targeted mutation 1, I David Weiner
• MGI ID: MGI:5477809
• Synonyms: floxed Rhbg
• Gene: Rhbg Location: Chr3:88150181-88162016 bp, - strand Genetic Position: Chr3, 38.78 cM
• Alliance: Rhbg^tm1.1Idw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195261
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5 and a floxed neo cassette was inserted downstream of exon 9 via homologous recombination. The neo cassette was then deleted following electroporation of a supercoiled Neo expression plasmid into the ES cells. (J:195261)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rhbg Mutation: 22 strains or lines available

References

• Original: J:195261 Bishop JM, et al., Role of the Rhesus glycoprotein, Rh B glycoprotein, in renal ammonia excretion. Am J Physiol Renal Physiol. 2010 Nov;299(5):F1065-77
• All: 4 reference(s)