Epn1^tm1.1Wami
Targeted Allele Detail

Summary

• Symbol: Epn1^tm1.1Wami
• Name: epsin 1; targeted mutation 1.1, Wang Min
• MGI ID: MGI:5477814
• Synonyms: Epn1^fl
• Gene: Epn1 Location: Chr7:5083234-5101177 bp, + strand Genetic Position: Chr7, 2.94 cM
• Alliance: Epn1^tm1.1Wami page

Reduced tumor growth in Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 and Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre)7Mlia/0 mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193966
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette and left exon 2 floxed. (J:193966)

Generation of the conditional Epn1^tm1.1Wami allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epn1 Mutation: 33 strains or lines available

References

• Original: J:193966 Pasula S, et al., Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest. 2012 Dec 3;122(12):4424-38
• All: 7 reference(s)