Tg(Myh6-icre/ERT2)#Wet
Transgene Detail

Summary

• Symbol: Tg(Myh6-icre/ERT2)#Wet
• Name: transgene insertion, Nina Wettschureck
• MGI ID: MGI:5477906
• Synonyms: alphaMHC-CreERT2
• Transgene: Tg(Myh6-icre/ERT2)#Wet Location: unknown
• Alliance: Tg(Myh6-icre/ERT2)#Wet page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Myh6-icre/ERT2)#Wet expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myh6 (MGI:97255)

• Mutation details: The mouse promoter drives cardiac-specific expression of a tamoxifen-inducible humanized cre (icre) fused to an estrogen receptor mutant (ERT2) followed by a bovine growth hormone polyadenylation sequence. Flp-mediated recombination removed an FRT-flanked Lactb gene. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:195335)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myh6 (mouse) Summary of all recombinase alleles driven by Myh6. Alliance mouse Myh6 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:195335 Takefuji M, et al., G(13)-mediated signaling pathway is required for pressure overload-induced cardiac remodeling and heart failure. Circulation. 2012 Oct 16;126(16):1972-82
• All: 18 reference(s)