Kcnq5^tm1.1Tjj
Targeted Allele Detail

Summary

• Symbol: Kcnq5^tm1.1Tjj
• Name: potassium voltage-gated channel, subfamily Q, member 5; targeted mutation 1.1, Thomas J Jentsch
• MGI ID: MGI:5478538
• Synonyms: Kcnq5^dn
• Gene: Kcnq5 Location: Chr1:21468627-22032166 bp, - strand Genetic Position: Chr1, 6.67 cM, cytoband A5
• Alliance: Kcnq5^tm1.1Tjj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195336
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Dominant negative) Mutation: Single point mutation Mutation details: A mutation was introduced into exon 6 which changed the first glycine of the GYG signature pore sequence to serine (G278S) and a floxed neo resistance cassette was inserted in intron 5. Subsequent cre expression excised the resistance cassette in properly targeted ES cells. (J:195336)

Generation of the Kcnq5^tm1.1Tjj allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcnq5 Mutation: 61 strains or lines available

References

• Original: J:195336 Tzingounis AV, et al., The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus. Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10232-7
• All: 4 reference(s)