Gip^tm1Nina
Targeted Allele Detail

Summary

• Symbol: Gip^tm1Nina
• Name: gastric inhibitory polypeptide; targeted mutation 1, Nobuya Inagaki
• MGI ID: MGI:5478539
• Synonyms: GIP-GFP
• Gene: Gip Location: Chr11:95915371-95921657 bp, + strand Genetic Position: Chr11, 59.21 cM
• Alliance: Gip^tm1Nina page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193877
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutation: Insertion Mutation details: An EGFP and floxed neo cassette were inserted into exon 3. Immunohistochemistry confirmed EGFP expression and absence of endogenous protein expression in the small intestine. (J:193877)

Generation of the Gip^tm1Nina allele

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gip Mutation: 13 strains or lines available

References

• Original: J:193877 Suzuki K, et al., Transcriptional regulatory factor X6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity. J Biol Chem. 2013 Jan 18;288(3):1929-38
• All: 11 reference(s)