Bub1^tm4.1Jvd
Targeted Allele Detail

Summary

• Symbol: Bub1^tm4.1Jvd
• Name: BUB1, mitotic checkpoint serine/threonine kinase; targeted mutation 4.1, Jan M A van Deursen
• MGI ID: MGI:5478549
• Synonyms: Bub1^F
• Gene: Bub1 Location: Chr2:127643036-127673785 bp, - strand Genetic Position: Chr2, 62.1 cM
• Alliance: Bub1^tm4.1Jvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195237
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 9. An additional loxP site was inserted usptream of exon 9. Flp-mediated recombination removed the neo cassette and left exon 9 floxed. (J:195237)

Generation of the Bub1^tm4.1Jvd allele

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
cn1	Bub1^tm4.1Jvd/Bub1^tm4.1Jvd	involves: 129S4/SvJaeSor

Phenotypes:

Affected Systems	cn1
show or hide all annotated terms
cellular	√
abnormal cell death	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bub1 Mutation: 52 strains or lines available

References

• Original: J:195237 Ricke RM, et al., Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression. J Cell Biol. 2012 Dec 10;199(6):931-49
• All: 1 reference(s)