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Pi4katm1.1Pdc
Targeted Allele Detail
Summary
Symbol: Pi4katm1.1Pdc
Name: phosphatidylinositol 4-kinase alpha; targeted mutation 1.1, Pietro De Camilli
MGI ID: MGI:5478561
Synonyms: PI4KIIIalphaf
Gene: Pi4ka  Location: Chr16:17098215-17224178 bp, - strand  Genetic Position: Chr16, 10.71 cM
Alliance: Pi4katm1.1Pdc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:195235
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J x 129S1/Sv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 48. An additional loxP site was inserted downstream of exon 52. Flp-mediated recombination removed the neo cassette and left exons 48 through 52 floxed. (J:195235)
Generation of the Pi4katm1.1Pdc and Pi4katm1.2Pdc alleles
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pi4ka Mutation:  126 strains or lines available
References
Original:  J:195235 Nakatsu F, et al., PtdIns4P synthesis by PI4KIIIalpha at the plasma membrane and its impact on plasma membrane identity. J Cell Biol. 2012 Dec 10;199(6):1003-16
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory