Siglec15^tm1Yohi
Targeted Allele Detail

Summary

• Symbol: Siglec15^tm1Yohi
• Name: sialic acid binding Ig-like lectin 15; targeted mutation 1, Yoshiharu Hiruma
• MGI ID: MGI:5478584
• Gene: Siglec15 Location: Chr18:78086829-78100610 bp, - strand Genetic Position: Chr18, 52.43 cM
• Alliance: Siglec15^tm1Yohi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193852
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exons 2 through 4, which encode most of the extracellular and transmembrane domains. (J:193852)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Siglec15 Mutation: 26 strains or lines available

References

• Original: J:193852 Hiruma Y, et al., Impaired osteoclast differentiation and function and mild osteopetrosis development in Siglec-15-deficient mice. Bone. 2013 Mar;53(1):87-93
• All: 2 reference(s)