Npm1^tm1Hft
Targeted Allele Detail

Summary

• Symbol: Npm1^tm1Hft
• Name: nucleophosmin 1; targeted mutation 1, Hwei-Fang Tien
• MGI ID: MGI:5478640
• Synonyms: Npm1^c+
• Gene: Npm1 Location: Chr11:33102287-33113206 bp, - strand Genetic Position: Chr11, 19.21 cM
• Alliance: Npm1^tm1Hft page

Splenomegaly and follicle structure changes in Npm1^tm1Hft/Npm1⁺ mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194999
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Humanized sequence) Mutation: Insertion Mutation details: Exon 11 was replaced with a floxed neo cassette and a modified exon 11 in which the wild-type sequence is replaced with a TCTG insertion after the coding sequence nucleotide 8657 (c.854_857dupTCTG). This "conventional" mutation mimics the human mutation observed in patients with acute myeloid leukemia (AML;type A, c.860_863dupTCTG) without any "humanized" sequence. (J:194999)

Generation of the Npm1^tm1Hft allele

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npm1 Mutation: 36 strains or lines available

References

• Original: J:194999 Chou SH, et al., A knock-in Npm1 mutation in mice results in myeloproliferation and implies a perturbation in hematopoietic microenvironment. PLoS One. 2012;7(11):e49769
• All: 1 reference(s)