Rbbp8^tm1.1Thl
Targeted Allele Detail

Summary

• Symbol: Rbbp8^tm1.1Thl
• Name: retinoblastoma binding protein 8, endonuclease; targeted mutation 1.1, Thomas Ludwig
• MGI ID: MGI:5484516
• Synonyms: CtIP^co
• Gene: Rbbp8 Location: Chr18:11766333-11876264 bp, + strand Genetic Position: Chr18, 5.85 cM
• Alliance: Rbbp8^tm1.1Thl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194603
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2, which encodes the N-terminal 36 amino acids and contains the translation initiation site, was floxed. Flp-mediated recombination removed the FRT-flanked neo cassette inserted downstream of exon 2. (J:194603)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbbp8 Mutation: 51 strains or lines available

References

• Original: J:194603 Bothmer A, et al., Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. J Exp Med. 2013 Jan 14;210(1):115-23
• All: 4 reference(s)