Gt(ROSA)26Sor^{tm1.1(CAG-PLS3,-GFP)Bwir}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(CAG-PLS3,-GFP)Bwir}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Brunhilde Wirth
• MGI ID: MGI:5484555
• Synonyms: PLS3V5^tg
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(CAG-PLS3,-GFP)Bwir} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193844
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(CAG-PLS3,-GFP)Bwir} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PLS3 (5358)

  Pls3	(MGI:104807)

• Mutation details: The construct inserted into the locus contains a CAG promoter, floxed neo/STOP cassette, human PLS3 cDNA with a V5-tag, IRES and GFP gene. Cre-mediated recombination removed the neo/STOP cassette. (J:193844)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:193844 Ackermann B, et al., Plastin 3 ameliorates spinal muscular atrophy via delayed axon pruning and improves neuromuscular junction functionality. Hum Mol Genet. 2013 Apr 1;22(7):1328-47
• All: 5 reference(s)