Hltf^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Hltf^tm1.1Arte
• Name: helicase-like transcription factor; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5484565
• Gene: Hltf Location: Chr3:20111975-20172654 bp, + strand Genetic Position: Chr3, 6.15 cM
• Alliance: Hltf^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193813
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and F3 flanked puro cassette were inserted upstream of exon 11 and a loxP site was inserted downstream of exon 13 via homologous recombination. Recombinase mediated recombination removed the selection cassette and exons 11-13. Western blot analysis confirmed the absence of protein expression in the hippocampus of homozygous mice. (J:193813)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hltf Mutation: 47 strains or lines available

References

• Original: J:193813 Oh YS, et al., SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action. Cell. 2013 Feb 14;152(4):831-43
• All: 1 reference(s)