Tg(tetO-Fbxl21*)11Jt
Transgene Detail

Summary

• Symbol: Tg(tetO-Fbxl21*)11Jt
• Name: transgene insertion 11, Joseph S Takahashi
• MGI ID: MGI:5484569
• Synonyms: tetO::Psttm
• Transgene: Tg(tetO-Fbxl21*)11Jt Location: unknown
• Alliance: Tg(tetO-Fbxl21*)11Jt page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-Fbxl21*)11Jt expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fbxl21 (MGI:2442921)

• Mutation details: A tetO promoter drives expression of a mouse Fbxl21 gene with a G to A mutation at nucleotide 787 resulting in a glycine to a glutamic acid mutation in amino acid 149 within the third leucine-rich repeat of the protein. (J:194037)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Tg(Scg2-tTA)1Jt/0 Tg(tetO-Fbxl21*)11Jt/0	involves: CD-1

Phenotypes:

Affected Systems	cx1
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behavior/neurological	√
shortened circadian behavior period	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:194037 Yoo SH, et al., Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm. Cell. 2013 Feb 28;152(5):1091-105
• All: 1 reference(s)