Sppl2a^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Sppl2a^tm1Dgen
• Name: signal peptide peptidase like 2A; targeted mutation 1, Deltagen
• MGI ID: MGI:5484576
• Gene: Sppl2a Location: Chr2:126732311-126775155 bp, - strand Genetic Position: Chr2, 61.76 cM, cytoband F3
• Alliance: Sppl2a^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194595
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Not Specified
• No details provided. (J:194595)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sppl2a Mutation: 47 strains or lines available

References

• Original: J:194595 Beisner DR, et al., The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain. J Exp Med. 2013 Jan 14;210(1):23-30
• All: 1 reference(s)