Edar^tm1.1Bamo
Targeted Allele Detail

Summary

• Symbol: Edar^tm1.1Bamo
• Name: ectodysplasin-A receptor; targeted mutation 1.1, Bruce A Morgan
• MGI ID: MGI:5484581
• Synonyms: 307A
• Gene: Edar Location: Chr10:58436611-58511476 bp, - strand Genetic Position: Chr10, 29.37 cM, cytoband B3
• Alliance: Edar^tm1.1Bamo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193816
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Single point mutation
• Mutation details: Homologous recombination was used to introduce a T1326C point mutation resulting in a V370A substitution in the protein in exon 12 and a floxed neo cassette in the untranslated region of exon 12. Cre mediated recombination removed the neo cassette. (J:193816)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Edar Mutation: 30 strains or lines available

References

• Original: J:193816 Kamberov YG, et al., Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant. Cell. 2013 Feb 14;152(4):691-702
• All: 1 reference(s)