Mc4r^tm2Lowl
Targeted Allele Detail

Summary

• Symbol: Mc4r^tm2Lowl
• Name: melanocortin 4 receptor; targeted mutation 2, Bradford B Lowell
• MGI ID: MGI:5484615
• Synonyms: Mc4r^flox, Mc4r^loxP
• Gene: Mc4r Location: Chr18:66990776-66993558 bp, - strand Genetic Position: Chr18, 39.72 cM, cytoband E1
• Alliance: Mc4r^tm2Lowl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193452
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: One loxP site was inserted in the 5'UTR and a second loxP site followed by a FRT-flanked kanamycin resistance cassette was inserted in the 3'UTR. The single coding exon is thus flanked by loxP sites. (J:193452, J:216397)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mc4r Mutation: 48 strains or lines available

References

• Original: J:193452 Sohn JW, et al., Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons. Cell. 2013 Jan 31;152(3):612-9
• All: 7 reference(s)