Mc4r^tm2.1Lowl
Targeted Allele Detail

Summary

• Symbol: Mc4r^tm2.1Lowl
• Name: melanocortin 4 receptor; targeted mutation 2.1, Bradford B Lowell
• MGI ID: MGI:5484616
• Synonyms: Mc4r^delta
• Gene: Mc4r Location: Chr18:66990776-66993558 bp, - strand Genetic Position: Chr18, 39.72 cM, cytoband E1
• Alliance: Mc4r^tm2.1Lowl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193452
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: One loxP site was inserted in the 5'UTR and a second loxP site followed by a FRT-flanked kanamycin resistance cassette was inserted in the 3'UTR. The single coding exon is thus flanked by loxP sites. The coding exon was subsequently excised in properly targeted mice by cre expression. (J:193452, J:216397)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mc4r Mutation: 48 strains or lines available

References

• Original: J:193452 Sohn JW, et al., Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons. Cell. 2013 Jan 31;152(3):612-9
• All: 5 reference(s)